Cambridge Healthtech Training Seminars offer real-life case studies, problems encountered and solutions applied, and extensive coverage of the basic science underlying each topic. Experienced Training Seminar instructors offer a mix of formal lectures, interactive discussions and activities to help attendees maximize their learning experiences. These immersive trainings will be of value to scientists from industry and academic research groups who are entering new fields – and to those working in supporting roles that will benefit from an in-depth briefing on a specific aspect of the industry.
Monday, August 27 - Tuesday, August 28
Dina Schneider, PhD, Manager, Cell Biology, Lentigen Technology, Inc.
This course is intended for academic and industry scientists new to the field of CAR T immunotherapy, and it offers an overview of basic concepts, strategies and tools in CAR T development. Topics will include the history of CAR T field, CAR structure and function, approaches to CAR gene delivery, target selection, the impact of CAR linkers and structural domains on function, multi-targeting CAR constructs, and the emerging technologies for temporal and spatial control of CAR T function.
- History of CAR T development
- Principles of CAR T structure and function
- Target identification
- Screening and selection of suitable binding domains
- Role of linkers and structural domains in CAR T function
- Role of tumor antigen expression in regulating CAR T activity
- Molecular boosters of CAR T function
- Approaches for temporal and spatial regulation of CAR T function
- Multi-targeting CAR T strategies to prevent disease escape
- Approaches to gene delivery for CAR T expression
- Future directions
Tuesday, August 28 - Wednesday, August 29
Masha Fridkis-Hareli, MSc, PhD, Founder and President, ATR, LLC
Tatiana Novobrantseva, PhD, Co-Founder, Head of Research and Development, Verseau Therapeutics
This 1.5-day seminar will cover the fundamentals of human immunology for an audience of scientists across different backgrounds working in pharmaceutical and biotech organizations in programs related to immunotherapy. The course will cover a historical perspective, basic mechanisms, fundamental concepts and practical approaches to developing therapeutics and their combinations to modulate the immune system. Additionally, the class will offer perspectives on how immune responses can be monitored by assessment of biomarkers and modulated through biopharmaceutical intervention. Through group activities, attendees will actively review immunological concepts as well as design functional immunological assays and read-outs.
- Introduction to the immune system
- Innate immunity
- Adaptive immunity
- Infections, inflammation and cancer
- Antigen generation, capture and presentation to lymphocytes
- Effector mechanisms of cellular immunity
- Antibody generation and antibody-mediated cytotoxicity
- History and mechanisms of checkpoint-based therapeutic approaches
- Engineered cellular therapies – CAR-T and dendritic cells
- Cancer vaccines
Training Seminar Information
Each CHI Training Seminar offers 1.5 days of instruction with start and stop times for each day shown above and on the Event-at-a-Glance published in the onsite Program & Event Guide. Training Seminars will include morning and afternoon refreshment breaks, as applicable, and lunch will be provided to all registered attendees on the full day of the class.
Each person registered specifically for the training seminar will be provided with a hard copy handbook for the seminar in which they are registered. A limited number of additional handbooks will be available for other delegates who wish to attend the seminar, but after these have been distributed, no additional books will be available.
Though CHI encourages track hopping between conference programs, we ask that Training Seminars not be disturbed once they have begun. In the interest of maintaining the highest quality learning environment for Training Seminar attendees, and because Seminars are conducted differently than conference programming, we ask that attendees commit to attending the entire program, and not engage in track hopping, as to not disturb the hands-on style instruction being offered to the other participants.